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In addition to L-cellspecific Bmal1 deletion, which directly establishes the requirement of BMAL1 for rhythmic GLP-1 release, mice lacking other core clock components (including Clock and Period genes) exhibit disrupted feeding behavior, impaired glucose homeostasis, and abnormal daily patterns of incretin secretion [13,19,50,51]

Neil Rawlins says it may take some as many as 4 months (at a therapeutic dose - for some that is as much as 15 mg) to notice that they are actually feeling better

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